| 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Basic information |
| Product Name: | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride |
| Synonyms: | 4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)PIPERIDINE;ASINEX-REAG BAS 13549338;6–3-(4-)-1,2 KY-16-05;Paliperidone Related CoMpound B;1,2-Benzisoxazole,6-fluoro-3-(4-piperidinyl)-, hydrochloride (1:1);Paliperidone int 2;Paliperidone Related Compound B (20 mg) (6-fluoro-3-(piperidin-4-yl)benzoisoxazole hydrochloride);Iloperidone intermediate |
| CAS: | 84163-13-3 |
| MF: | C12H14ClFN2O |
| MW: | 256.7 |
| EINECS: | 700-303-4 |
| Product Categories: | Pharmaceutical Intermediates |
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| 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Chemical Properties |
| Melting point | 293-295 °C |
| density | 1.42g/cm3 at 20℃ |
| vapor pressure | 0.002-0.005Pa at 20-25℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Very Slightly, Heated), Water (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
| LogP | -0.84 at 20℃ and pH7 |
| CAS DataBase Reference | 84163-13-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2934990002 |
| 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Usage And Synthesis |
| Uses | 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole Hydrochloride (Risperidone EP Impurity M; Paliperidone USP Related Compound B) is a novel antiproliferative agent. |
| 6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride Preparation Products And Raw materials |
| Raw materials | 1-Piperidinecarboxaldehyde, 4-(6-fluoro-1,2-benzisoxazol-3-yl)—>1-Piperidinecarboxaldehyde, 4-[(2,4-difluorophenyl)(hydroxyimino)methyl]—>1-FORMYL-PIPERIDINE-4-CARBONYL CHLORIDE–>4-(2,4-DIFLUORO-BENZOYL)-PIPERIDINE-1-CARBALDEHYDE–>2,4-Difluorobenzaldehyde–>1-Methylpiperdin-4-ylmagnesium chloride, 0.50 M in THF–>2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime–>2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride–>Isonipecotic acid–>1,3-Difluorobenzene |
| Preparation Products | Risperidone–>Iloperidone-d3–>3-(1-(3-CHLOROPROPYL)PIPERIDIN-4-YL)-6-FLUOROBENZO[D]ISOXAZOLE–>Paliperidone Palmitate |
